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Integrated analysis of environmental and genetic influences on cord blood DNA methylation in new-borns

Czamara, D (author)
Eraslan, G (author)
Page, CM (author)
show more...
Lahti, J (author)
Lahti-Pulkkinen, M (author)
Hamalainen, E (author)
Kajantie, E (author)
Laivuori, H (author)
Villa, PM (author)
Reynolds, RM (author)
Nystad, W (author)
Haberg, SE (author)
London, SJ (author)
O'Donnell, KJ (author)
Garg, E (author)
Meaney, MJ (author)
Entringer, S (author)
Wadhwa, PD (author)
Buss, C (author)
Jones, MJ (author)
Lin, DTS (author)
MacIsaac, JL (author)
Kobor, MS (author)
Koen, N (author)
Zar, HJ (author)
Koenen, KC (author)
Dalvie, S (author)
Stein, DJ (author)
Kondofersky, I (author)
Muller, NS (author)
Theis, FJ (author)
Raikkonen, K (author)
Binder, EB (author)
Wray, NR (author)
Ripke, S (author)
Mattheisen, M (author)
Trzaskowski, M (author)
Byrne, EM (author)
Abdellaoui, A (author)
Adams, MJ (author)
Agerbo, E (author)
Air, TM (author)
Andlauer, TFM (author)
Bacanu, SA (author)
Baekvad-Hansen, M (author)
Beekman, ATF (author)
Bigdeli, TB (author)
Blackwood, DHR (author)
Bryois, J (author)
Karolinska Institutet
Buttenschon, HN (author)
Bybjerg-Grauholm, J (author)
Cai, N (author)
Castelao, E (author)
Christensen, JH (author)
Clarke, TK (author)
Coleman, JR (author)
Colodro-Conde, L (author)
Couvy-Duchesne, B (author)
Craddock, N (author)
Crawford, GE (author)
Davies, G (author)
Deary, IJ (author)
Degenhardt, F (author)
Derks, EM (author)
Direk, N (author)
Dolan, C (author)
Dunn, EC (author)
Eley, TC (author)
Escott-Price, V (author)
Kiadeh, FFH (author)
Finucane, HK (author)
Forstner, AJ (author)
Frank, J (author)
Gaspar, HA (author)
Gill, M (author)
Goes, FS (author)
Gordon, SD (author)
Grove, J (author)
Hall, LS (author)
Hansen, CS (author)
Hansen, TF (author)
Herms, S (author)
Hickie, IB (author)
Hoffmann, P (author)
Homuth, G (author)
Horn, C (author)
Hottenga, JJ (author)
Hougaard, DM (author)
Ising, M (author)
Jansen, R (author)
Jorgenson, E (author)
Knowles, JA (author)
Kohane, IS (author)
Kraft, J (author)
Kretzschmar, WW (author)
Krogh, J (author)
Kutalik, Z (author)
Li, YH (author)
Lind, PA (author)
MacIntyre, DJ (author)
MacKinnon, DF (author)
Maier, RM (author)
Maier, W (author)
Marchini, J (author)
Mbarek, H (author)
McGrath, P (author)
McGuffin, P (author)
Medland, SE (author)
Mehta, D (author)
Middeldorp, CM (author)
Mihailov, E (author)
Milaneschi, Y (author)
Milani, L (author)
Mondimore, FM (author)
Montgomery, GW (author)
Mostafavi, S (author)
Mullins, N (author)
Nauck, M (author)
Ng, B (author)
Nivard, MG (author)
Nyholt, DR (author)
O'Reilly, PF (author)
Oskarsson, H (author)
Owen, MJ (author)
Painter, JN (author)
Pedersen, CB (author)
Pedersen, MG (author)
Peterson, RE (author)
Pettersson, E (author)
Peyrot, WJ (author)
Pistis, G (author)
Posthuma, D (author)
Quiroz, JA (author)
Qvist, P (author)
Rice, JP (author)
Riley, BP (author)
Rivera, M (author)
Mirza, SS (author)
Schoevers, R (author)
Schulte, EC (author)
Shen, L (author)
Shi, JX (author)
Shyn, S (author)
Sigurdsson, E (author)
Sinnamon, GCB (author)
Smit, JH (author)
Smith, DJ (author)
Stefansson, H (author)
Steinberg, S (author)
Streit, F (author)
Strohmaier, J (author)
Tansey, KE (author)
Teismann, H (author)
Teumer, A (author)
Thompson, W (author)
Thomson, PA (author)
Thorgeirsson, TE (author)
Traylor, M (author)
Treutlein, J (author)
Trubetskoy, V (author)
Uitterlinden, AG (author)
Umbricht, D (author)
Van der Auwera, S (author)
van Hemert, AM (author)
Viktorin, A (author)
Karolinska Institutet
Visscher, PM (author)
Wang, YP (author)
Webb, BT (author)
Weinsheimer, SM (author)
Wellmann, J (author)
Willemsen, G (author)
Witt, SH (author)
Wu, Y (author)
Xi, HLS (author)
Yang, J (author)
Zhang, FT (author)
Arolt, V (author)
Baune, BT (author)
Berger, K (author)
Boomsma, D (author)
Cichon, S (author)
Dannlowski, U (author)
de Geus, EJC (author)
DePaulo, JR (author)
Domenici, E (author)
Domschke, K (author)
Esko, T (author)
Grabe, HJ (author)
Hamilton, SP (author)
Hayward, C (author)
Heath, AC (author)
Kendler, KS (author)
Kloiber, S (author)
Lewis, G (author)
Li, QQS (author)
Lucae, S (author)
Madden, PAF (author)
Magnusson, PK (author)
Karolinska Institutet
Martin, NG (author)
McIntosh, AM (author)
Metspalu, A (author)
Mors, O (author)
Mortensen, PB (author)
Muller-Myhsok, B (author)
Nordentoft, M (author)
Nothen, MM (author)
O'Donovan, MC (author)
Paciga, SA (author)
Pedersen, NL (author)
Karolinska Institutet
Penninx, BWJH (author)
Perlis, RH (author)
Porteous, DJ (author)
Potash, JB (author)
Preisig, M (author)
Rietschel, M (author)
Schaefer, C (author)
Schulze, TG (author)
Smoller, JW (author)
Stefansson, K (author)
Tiemeier, H (author)
Uher, R (author)
Volzke, H (author)
Weissman, MM (author)
Werge, T (author)
Lewis, CM (author)
Levinson, DF (author)
Breen, G (author)
Borglum, AD (author)
Sullivan, PF (author)
show less...
 (creator_code:org_t)
2019-06-11
2019
English.
In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 10:1, s. 2548-
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Epigenetic processes, including DNA methylation (DNAm), are among the mechanisms allowing integration of genetic and environmental factors to shape cellular function. While many studies have investigated either environmental or genetic contributions to DNAm, few have assessed their integrated effects. Here we examine the relative contributions of prenatal environmental factors and genotype on DNA methylation in neonatal blood at variably methylated regions (VMRs) in 4 independent cohorts (overall n = 2365). We use Akaike’s information criterion to test which factors best explain variability of methylation in the cohort-specific VMRs: several prenatal environmental factors (E), genotypes in cis (G), or their additive (G + E) or interaction (GxE) effects. Genetic and environmental factors in combination best explain DNAm at the majority of VMRs. The CpGs best explained by either G, G + E or GxE are functionally distinct. The enrichment of genetic variants from GxE models in GWAS for complex disorders supports their importance for disease risk.

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By the author/editor
Czamara, D
Eraslan, G
Page, CM
Lahti, J
Lahti-Pulkkinen, ...
Hamalainen, E
show more...
Kajantie, E
Laivuori, H
Villa, PM
Reynolds, RM
Nystad, W
Haberg, SE
London, SJ
O'Donnell, KJ
Garg, E
Meaney, MJ
Entringer, S
Wadhwa, PD
Buss, C
Jones, MJ
Lin, DTS
MacIsaac, JL
Kobor, MS
Koen, N
Zar, HJ
Koenen, KC
Dalvie, S
Stein, DJ
Kondofersky, I
Muller, NS
Theis, FJ
Raikkonen, K
Binder, EB
Wray, NR
Ripke, S
Mattheisen, M
Trzaskowski, M
Byrne, EM
Abdellaoui, A
Adams, MJ
Agerbo, E
Air, TM
Andlauer, TFM
Bacanu, SA
Baekvad-Hansen, ...
Beekman, ATF
Bigdeli, TB
Blackwood, DHR
Bryois, J
Buttenschon, HN
Bybjerg-Grauholm ...
Cai, N
Castelao, E
Christensen, JH
Clarke, TK
Coleman, JR
Colodro-Conde, L
Couvy-Duchesne, ...
Craddock, N
Crawford, GE
Davies, G
Deary, IJ
Degenhardt, F
Derks, EM
Direk, N
Dolan, C
Dunn, EC
Eley, TC
Escott-Price, V
Kiadeh, FFH
Finucane, HK
Forstner, AJ
Frank, J
Gaspar, HA
Gill, M
Goes, FS
Gordon, SD
Grove, J
Hall, LS
Hansen, CS
Hansen, TF
Herms, S
Hickie, IB
Hoffmann, P
Homuth, G
Horn, C
Hottenga, JJ
Hougaard, DM
Ising, M
Jansen, R
Jorgenson, E
Knowles, JA
Kohane, IS
Kraft, J
Kretzschmar, WW
Krogh, J
Kutalik, Z
Li, YH
Lind, PA
MacIntyre, DJ
MacKinnon, DF
Maier, RM
Maier, W
Marchini, J
Mbarek, H
McGrath, P
McGuffin, P
Medland, SE
Mehta, D
Middeldorp, CM
Mihailov, E
Milaneschi, Y
Milani, L
Mondimore, FM
Montgomery, GW
Mostafavi, S
Mullins, N
Nauck, M
Ng, B
Nivard, MG
Nyholt, DR
O'Reilly, PF
Oskarsson, H
Owen, MJ
Painter, JN
Pedersen, CB
Pedersen, MG
Peterson, RE
Pettersson, E
Peyrot, WJ
Pistis, G
Posthuma, D
Quiroz, JA
Qvist, P
Rice, JP
Riley, BP
Rivera, M
Mirza, SS
Schoevers, R
Schulte, EC
Shen, L
Shi, JX
Shyn, S
Sigurdsson, E
Sinnamon, GCB
Smit, JH
Smith, DJ
Stefansson, H
Steinberg, S
Streit, F
Strohmaier, J
Tansey, KE
Teismann, H
Teumer, A
Thompson, W
Thomson, PA
Thorgeirsson, TE
Traylor, M
Treutlein, J
Trubetskoy, V
Uitterlinden, AG
Umbricht, D
Van der Auwera, ...
van Hemert, AM
Viktorin, A
Visscher, PM
Wang, YP
Webb, BT
Weinsheimer, SM
Wellmann, J
Willemsen, G
Witt, SH
Wu, Y
Xi, HLS
Yang, J
Zhang, FT
Arolt, V
Baune, BT
Berger, K
Boomsma, D
Cichon, S
Dannlowski, U
de Geus, EJC
DePaulo, JR
Domenici, E
Domschke, K
Esko, T
Grabe, HJ
Hamilton, SP
Hayward, C
Heath, AC
Kendler, KS
Kloiber, S
Lewis, G
Li, QQS
Lucae, S
Madden, PAF
Magnusson, PK
Martin, NG
McIntosh, AM
Metspalu, A
Mors, O
Mortensen, PB
Muller-Myhsok, B
Nordentoft, M
Nothen, MM
O'Donovan, MC
Paciga, SA
Pedersen, NL
Penninx, BWJH
Perlis, RH
Porteous, DJ
Potash, JB
Preisig, M
Rietschel, M
Schaefer, C
Schulze, TG
Smoller, JW
Stefansson, K
Tiemeier, H
Uher, R
Volzke, H
Weissman, MM
Werge, T
Lewis, CM
Levinson, DF
Breen, G
Borglum, AD
Sullivan, PF
show less...
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Nature communica ...
By the university
Karolinska Institutet

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